Title : Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission.

Pub. Date : 2015 Sep 15

PMID : 26240176






1 Functional Relationships(s)
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1 Compared to cells expressing wild-type or constitutively active vinculin, we found reduced tractions, cytoskeletal stiffness, adhesion strength, and increased vinculin dynamics in cells expressing constitutively inactive vinculin or vinculin where Src-mediated phosphorylation was blocked by replacing tyrosine at position 100 and/or 1065 with a non-phosphorylatable phenylalanine residue. Phenylalanine vinculin Mus musculus