Title : Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa.

Pub. Date : 2015 Nov

PMID : 26228509






1 Functional Relationships(s)
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1 KEY RESULTS: The expression levels of 3beta-HSD, CYP21, 11beta-HSD1 and CYP11B1 increased in human epithelial cells treated with clarithromycin and azithromycin, whereas the expression levels of 11beta-HSD2 and CYP11A1 were not affected. Clarithromycin cytochrome P450 family 11 subfamily A member 1 Homo sapiens