Title : Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa.

Pub. Date : 2015 Nov

PMID : 26228509






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 KEY RESULTS: The expression levels of 3beta-HSD, CYP21, 11beta-HSD1 and CYP11B1 increased in human epithelial cells treated with clarithromycin and azithromycin, whereas the expression levels of 11beta-HSD2 and CYP11A1 were not affected. Azithromycin hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens
2 The expression of 3beta-HSD, CYP11A1, CYP21, CYP11B1 and 11beta-HSD1 was upregulated in nasal mucosa of mice treated with clarithromycin or azithromycin, but not in adrenalectomized mice. Azithromycin hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens