Title : Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles.

Pub. Date : 2015 Sep 1

PMID : 26226543






2 Functional Relationships(s)
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1 The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins cytochrome P450 family 1 subfamily B member 1 Homo sapiens