Pub. Date : 2015 Sep 4
PMID : 26225749
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | The tumor inhibitory effect of metformin on p53-mutated breast cancer cells remains unclear. | Metformin | tumor protein p53 | Homo sapiens |
| 3 | Data from the present study demonstrated that p53 knockdown or mutation has a negative effect on metformin or phenformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. | Metformin | tumor protein p53 | Homo sapiens |
| 4 | We also found that p53 reactivating agent nutlin-3alpha and CP/31398 promoted metformin-induced growth inhibition, senescence and apoptosis in MCF-7 (wt p53) and MDA-MB-231 (mt p53) cells, respectively. | Metformin | tumor protein p53 | Homo sapiens |
| 5 | We also found that p53 reactivating agent nutlin-3alpha and CP/31398 promoted metformin-induced growth inhibition, senescence and apoptosis in MCF-7 (wt p53) and MDA-MB-231 (mt p53) cells, respectively. | Metformin | tumor protein p53 | Homo sapiens |
| 6 | We also found that p53 reactivating agent nutlin-3alpha and CP/31398 promoted metformin-induced growth inhibition, senescence and apoptosis in MCF-7 (wt p53) and MDA-MB-231 (mt p53) cells, respectively. | Metformin | tumor protein p53 | Homo sapiens |
| 7 | Treatment of MCF-7 cells with metformin or phenformin induced increase in p53 protein levels and the transcription of its downstream target genes, Bax and p21, in a dose-dependent manner. | Metformin | tumor protein p53 | Homo sapiens |
| 8 | Moreover, we demonstrated that AMPK-mTOR signaling played a role in metformin-induced p53 up-regulation. | Metformin | tumor protein p53 | Homo sapiens |
| 9 | The present study showed that p53 is required for metformin or phenformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. | Metformin | tumor protein p53 | Homo sapiens |
| 10 | The combination of metformin with p53 reactivating agents, like nutlin-3alpha and CP/31398, is a promising strategy for improving metformin-mediated anti-cancer therapy, especially for tumors with p53 mutations. | Metformin | tumor protein p53 | Homo sapiens |
| 11 | The combination of metformin with p53 reactivating agents, like nutlin-3alpha and CP/31398, is a promising strategy for improving metformin-mediated anti-cancer therapy, especially for tumors with p53 mutations. | Metformin | tumor protein p53 | Homo sapiens |
| 12 | The combination of metformin with p53 reactivating agents, like nutlin-3alpha and CP/31398, is a promising strategy for improving metformin-mediated anti-cancer therapy, especially for tumors with p53 mutations. | Metformin | tumor protein p53 | Homo sapiens |