Title : Two Distinct Hepatitis C Virus Genotype 1a Clades Have Different Geographical Distribution and Association With Natural Resistance to NS3 Protease Inhibitors.

Pub. Date : 2015 Apr

PMID : 26213689






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The prevalence of the natural NS3 variant Q80K, associated with resistance to the macrocyclic protease inhibitor simeprevir, was detected in 51.6% of clade I and 0% of clade II (P < .001); clade I showed a lower genetic barrier for Q80K, whereas no sign of selective pressure at any protease inhibitor resistance-associated codon was detected. Simeprevir KRAS proto-oncogene, GTPase Homo sapiens