Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.

Pub. Date : 2016 Feb 26

PMID : 26210933






4 Functional Relationships(s)
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1 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
3 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
4 Several oximes with superior reactivating potency towards selective OP-AChE conjugates were identified but none of the tested oximes can be considered as a broad spectrum reactivator. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens