Title : The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β.

Pub. Date : 2015 Oct

PMID : 26208882






1 Functional Relationships(s)
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1 Furthermore, we found that the down-regulation of Ndrg2 in Ndrg2-deficient mice and imipramine treatment improved mood behavior with enhanced phosphorylation of GSK3beta through activation of PI3K/AKT signaling, suggesting that the expression level of NDRG2 has a causal influence on mood-related phenotypes. Imipramine glycogen synthase kinase 3 beta Mus musculus