Pub. Date : 2015 Oct
PMID : 26208523
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | In the p53-proficient colorectal cancer cell line HCT116, oxaliplatin represses the expression of deoxyuridine triphosphatase (dUTPase), a ubiquitous pyrophosphatase that catalyzes the hydrolysis of dUTP to dUMP and inhibits dUTP-mediated cytotoxicity. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | Oxaliplatin induced early p53 accumulation, upregulation of primary miR-34a transcript expression, and subsequent downregulation of E2F3 and E2F1. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 4 | In addition to DUT-N, oxaliplatin repressed, in a p53-dependent manner, the expression of genes encoding enzymes involved in thymidylate biosynthesis. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 5 | Consequently, oxaliplatin significantly decreased the level of dTTP in the dNTP pool in a p53-dependent manner. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 6 | These data indicate that the DACH carrier ligand in oxaliplatin triggers signaling via the p53-miR-34a-E2F axis, leading to transcriptional regulation that ultimately results in accumulation of dUTP and reduced dTTP biosynthesis, potentially enhancing 5-FU cytotoxicity. | Oxaliplatin | tumor protein p53 | Homo sapiens |