Pub. Date : 2015 Oct
PMID : 26208523
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Consequently, oxaliplatin significantly decreased the level of dTTP in the dNTP pool in a p53-dependent manner. | thymidine 5'-triphosphate | tumor protein p53 | Homo sapiens |
2 | These data indicate that the DACH carrier ligand in oxaliplatin triggers signaling via the p53-miR-34a-E2F axis, leading to transcriptional regulation that ultimately results in accumulation of dUTP and reduced dTTP biosynthesis, potentially enhancing 5-FU cytotoxicity. | thymidine 5'-triphosphate | tumor protein p53 | Homo sapiens |