Title : The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis.

Pub. Date : 2015 Oct

PMID : 26208523






2 Functional Relationships(s)
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1 Consequently, oxaliplatin significantly decreased the level of dTTP in the dNTP pool in a p53-dependent manner. thymidine 5'-triphosphate tumor protein p53 Homo sapiens
2 These data indicate that the DACH carrier ligand in oxaliplatin triggers signaling via the p53-miR-34a-E2F axis, leading to transcriptional regulation that ultimately results in accumulation of dUTP and reduced dTTP biosynthesis, potentially enhancing 5-FU cytotoxicity. thymidine 5'-triphosphate tumor protein p53 Homo sapiens