Pub. Date : 2016
PMID : 26202203
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This review briefly describes the newer aspects of MGMT posttranslational regulation by ubiquitination, sumoylation and glutathionylation and reveals how the reactivity of the active site Cys145 can be exploited for potent inhibition and depletion of MGMT by thiol-reacting drugs such as the disulfiram and various dithiocarbamate derivatives. | Dithiocarbamate | O-6-methylguanine-DNA methyltransferase | Homo sapiens |