Title : 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.

Pub. Date : 2015 Jul 22

PMID : 26198749






1 Functional Relationships(s)
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1 RESULTS: 3-BrPA could activate dose-dependent apoptosis (type 1 PCD) and regulated necrosis (type 3 PCD) of T24 (grade III; H-Ras(G12V); p53(DeltaY126)), but not RT4 (grade I), cells, with PARP, MLKL, Drp1 and Nec-7-targeted components critically orchestrating necrotic death. bromopyruvate poly(ADP-ribose) polymerase 1 Homo sapiens