Pub. Date : 2016 Jun
PMID : 26198481
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The glucocorticoid receptor (GR), a transcription factor regulating gene expression in a ligand-dependent fashion, is known for flexibility in adapting various ligands with their structures ranging from steroid to non-steroid. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |
| 2 | The glucocorticoid receptor (GR), a transcription factor regulating gene expression in a ligand-dependent fashion, is known for flexibility in adapting various ligands with their structures ranging from steroid to non-steroid. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |
| 3 | The glucocorticoid receptor (GR), a transcription factor regulating gene expression in a ligand-dependent fashion, is known for flexibility in adapting various ligands with their structures ranging from steroid to non-steroid. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |
| 4 | The glucocorticoid receptor (GR), a transcription factor regulating gene expression in a ligand-dependent fashion, is known for flexibility in adapting various ligands with their structures ranging from steroid to non-steroid. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |
| 5 | However, in our previous study, GR shows a stringent discrimination against a set of steroid ligands with highly similar structures for triggering its nuclear migration. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |
| 6 | By analyzing the docking orientations and the related ligand-GR interaction patterns, we found that the hydrophilicity mismatch between the docking ligand and the GR ligand-binding site is the main cause combined with the steric hindrance and structural rigidness of these steroid ligands. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |
| 7 | Furthermore, we utilized this knowledge to rationalize how the structure-binding interaction of non-steroid ligands triggers GR nuclear migration with their structures available in Protein Data Bank. | Steroids | nuclear receptor subfamily 3 group C member 1 | Homo sapiens |