Title : Effect of pyridostigmine and syntostigmine pretreatment on the inhibition of acetylcholinesterases by o-pinacolyl-methylphosphonofluoridate. In vitro experiments with rat tissues.

Pub. Date : 1989

PMID : 2619740






3 Functional Relationships(s)
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1 The inhibition kinetics of O-pinacolyl-methylphosphonofluoridate and two carbamates (pyridostigmine and syntostigmine) on the acetylcholinesterase from rat erythrocytes, brain and diaphragm have been studied in vitro. Neostigmine acetylcholinesterase Rattus norvegicus
2 In vitro addition of pyridostigmine and/or syntostigmine to acetylcholinesterase prior to the organophosphate provided a weak protection against acetylcholinesterase inhibition by this potent organo-phosphorous inhibitor. Neostigmine acetylcholinesterase Rattus norvegicus
3 In vitro addition of pyridostigmine and/or syntostigmine to acetylcholinesterase prior to the organophosphate provided a weak protection against acetylcholinesterase inhibition by this potent organo-phosphorous inhibitor. Neostigmine acetylcholinesterase Rattus norvegicus