Title : Aggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex.

Pub. Date : 2015 Sep 4

PMID : 26195632






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Therefore, we propose that polyQ-expanded Atx7 forms insoluble aggregates that sequester USP22 into a catalytically inactive state, and then the impaired DUBm loses the function to deubiquitinate monoubiquitinated histone H2B or H2A. polyglutamine H2A clustered histone 18 Homo sapiens