Title : Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes.

Pub. Date : 2015 Dec

PMID : 26190022






1 Functional Relationships(s)
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1 This paper reports that wild-type and Italian-mutant Abeta both form fibrils characterized by the cross-beta architecture, but with distinct beta-sheet organizations, resulting in differences in thioflavin T fluorescence and solvent accessibility. thioflavin T amyloid beta precursor protein Homo sapiens