Pub. Date : 2016 Jan
PMID : 26188014
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG). | isocitric acid | isocitrate dehydrogenase (NADP(+)) 2 | Homo sapiens |