Title : P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway.

Pub. Date : 2015

PMID : 26182292






4 Functional Relationships(s)
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1 Here, we found that extracellular ATP/UTP induced activation of EGFR and ERK1/2. Adenosine Triphosphate mitogen-activated protein kinase 3 Homo sapiens
2 After knockdown of P2Y2 receptor, the ATP -stimulated phosphorylation of EGFR and ERK1/2 was significantly suppressed. Adenosine Triphosphate mitogen-activated protein kinase 3 Homo sapiens
3 Further experiments showed that inactivation of EGFR and ERK1/2 attenuated ATP-induced invasion and migration, and suppressed ATP-mediated IL-8 production. Adenosine Triphosphate mitogen-activated protein kinase 3 Homo sapiens
4 Further experiments showed that inactivation of EGFR and ERK1/2 attenuated ATP-induced invasion and migration, and suppressed ATP-mediated IL-8 production. Adenosine Triphosphate mitogen-activated protein kinase 3 Homo sapiens