Title : Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors.

Pub. Date : 2015 Oct

PMID : 26177858






1 Functional Relationships(s)
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1 KEY RESULTS: EPA offered significant cytoprotection by increasing EPA/AA ratios in cell membranes, inhibiting ROS generation, enhancing antioxidant status and modulating nuclear translocation of redox-sensitive transcription factors (NF-kappaB p65 and Nrf-2) and expression of NF-kappaB p65, COX-2 and Nrf-2. Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens