Title : Palladium-Catalyzed Regioselective Alkynylation of Pyrroles and Azoles under Mild Conditions: Application to the Synthesis of a Dopamine D-4 Receptor Agonist.

Pub. Date : 2015 Aug 7

PMID : 26176588






1 Functional Relationships(s)
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1 Using a simple catalytic system such as Pd(OAc)2 (2.5 mol %), P(tBu)2Me HBF4 (5 mol %), and NaOAc (2 equiv) allowed the regioselective introduction of various alkynyl residues at the C-2 position of pyrroles. Sodium Acetate complement C2 Homo sapiens