Pub. Date : 2015 Jul
PMID : 26171059
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERK and its upstream activator MAPK kinase (MEK) are also involved in LPA-induced motility/migration of cancer cells. | lysophosphatidic acid | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | ERK and its upstream activator MAPK kinase (MEK) are also involved in LPA-induced motility/migration of cancer cells. | lysophosphatidic acid | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | PKG II also inhibited the activation of PI3K/Akt and MEK/ERK mediated signaling, which is important for LPA-induced Rac1 activation. | lysophosphatidic acid | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | These results suggest that PKG II affects LPA-stimulated migration of AGS cells by blocking Rac1 activation, via inhibition of PI3K/Akt and MEK/ERK mediated signaling. | lysophosphatidic acid | mitogen-activated protein kinase 1 | Homo sapiens |