Pub. Date : 2015 Oct
PMID : 26168875
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated whether IL-1beta affects the GABA-evoked currents (I(GABA)) in TLE tissue from humans. | gamma-Aminobutyric Acid | interleukin 1 beta | Homo sapiens |
| 2 | In this study, we investigated whether IL-1beta affects the GABA-evoked currents (I(GABA)) in TLE tissue from humans. | gamma-Aminobutyric Acid | interleukin 1 beta | Homo sapiens |
| 3 | We report the novel finding that pathophysiological concentrations of IL-1beta decreased the I(GABA) amplitude by up to 30% in specimens from patients with TLE with or without HS, but not in control tissues. | gamma-Aminobutyric Acid | interleukin 1 beta | Homo sapiens |
| 4 | Our findings suggest a novel mechanism possibly underlying the ictogenic action of IL-1beta, thus suggesting that this cytokine contributes to seizure generation in human TLE by reducing GABA-mediated neurotransmission. | gamma-Aminobutyric Acid | interleukin 1 beta | Homo sapiens |