Pub. Date : 2015 Sep
PMID : 26166692
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also found that insulin receptor substrate-1 (IRS-1), a component of insulin signaling, was negatively regulated by NLRP3 and IL-1beta, and that IL-1beta inhibited insulin-induced glucose uptake in myoblasts. | Glucose | interleukin 1 beta | Mus musculus |
| 2 | These results suggest that PLIN2 inhibits insulin-induced glucose uptake by activating NLRP3, caspase-1 and IL-1beta, leading to a decreased IRS-1 expression. | Glucose | interleukin 1 beta | Mus musculus |