Pub. Date : 2015 Oct 5
PMID : 26165762
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study was designed to determine whether low dose morphine treatment in mice could influence the spinal activity of ERK. | Morphine | mitogen-activated protein kinase 1 | Mus musculus |
| 2 | The data showed that morphine (1 microg/kg) induced a marked increase in ERK phosphorylation. | Morphine | mitogen-activated protein kinase 1 | Mus musculus |
| 3 | Intrathecal pre-treatment with a selective mitogen-activated and extracellular signal-regulated kinase (MEK) inhibitor PD98059, attenuated morphine-associated thermal hyperalgesia. | Morphine | mitogen-activated protein kinase 1 | Mus musculus |
| 4 | Morphine exposure increased phosphorylation of c-JUN, that was prevented by the inhibition of ERK pathway. | Morphine | mitogen-activated protein kinase 1 | Mus musculus |
| 5 | These data suggest that ERK contributes to the morphine-induced hyperalgesia by regulating the activation of c-JUN. | Morphine | mitogen-activated protein kinase 1 | Mus musculus |