Title : COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.

Pub. Date : 2015 Oct 1

PMID : 26160915






2 Functional Relationships(s)
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1 Complete loss of COA6 activity using gene editing in HEK293T cells resulted in a profound growth defect due to complex IV deficiency, caused by impaired biogenesis of the copper-bound mitochondrial DNA-encoded subunit COX2 and subsequent accumulation of complex IV assembly intermediates. Copper mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Our data reveal that COA6 is intricately involved in the copper-dependent biogenesis of COX2. Copper mitochondrially encoded cytochrome c oxidase II Homo sapiens