Title : Calcitriol Suppressed Inflammatory Reactions in IL-1β-Stimulated Human Periodontal Ligament Cells.

Pub. Date : 2015 Dec

PMID : 26156812






2 Functional Relationships(s)
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1 Calcitriol inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 20, CXC chemokine ligand (CXCL) 10, and matrix metalloproteinase (MMP)-3 release from IL-1beta-stimulated HPDLC. Calcitriol interleukin 6 Homo sapiens
2 Moreover, we found c-jun N-terminal kinase (JNK) phosphorylation and IkappaB-alpha degradation in IL-1beta-stimulated HPDLC were inhibited by calcitriol, and JNK and nuclear factor (NF)-kappaB inhibitors could decrease IL-6, IL-8, CCL20, CXCL10, and MMP-3 productions in IL-1beta-treated HPDLC. Calcitriol interleukin 6 Homo sapiens