Pub. Date : 2015 Sep
PMID : 26156677
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using mutational analysis and computational study, we determine that Arg316 in RXRalpha, essential for 9-cis-retinoic acid binding and activating RXRalpha transactivation, is not required for antagonist effects of N-6, whereas Trp305 and Phe313 are crucial for N-6 binding to RXRalpha by forming extra pi-pi stacking interactions with N-6, indicating a distinct RXRalpha binding mode of N-6. | Alitretinoin | retinoid X receptor alpha | Homo sapiens |