Pub. Date : 2015
PMID : 26156624
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 2 | In the current study, we analyzed whether pioglitazone, an agonist of PPARgamma, reduces angiotensin II-induced vascular lipid accumulation. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 3 | RESULTS: Pioglitazone significantly reduced angiotensin II-induced enhanced lipid deposition and superoxide production in the adventitia of the aorta, as detected by oil red O and dihydroethidium (DHE) staining, respectively. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 4 | Angiotensin II-induced upregulation of the expression of LDL receptor and Nox1 was inhibited by pioglitazone treatment. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 5 | In addition, angiotensin II significantly reduced the expression of PCSK9, and this reduction was ameliorated by pioglitazone. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 6 | On the other hand, pioglitazone did not significantly alter the expression of the phosphorylated forms of AMPKalpha and ACC, which was downregulated by angiotensin II. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 7 | CONCLUSIONS: Pioglitazone treatment suppressed excess lipid accumulation and superoxide production in the aorta in an angiotensin II-induced rat model of hypertension. | Pioglitazone | angiotensinogen | Rattus norvegicus |