Pub. Date : 2015 Nov
PMID : 26153065
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Buprenorphine, a maintenance drug for heroin addicts, exerts its pharmacological function via kappa- (KOP), mu-opioid (MOP) and nociceptin/opioid receptor-like 1 (NOP) receptors. | Buprenorphine | opioid receptor mu 1 | Homo sapiens |
| 2 | Buprenorphine, when applied acutely, inhibited AC activity to ~90% in cells expressing KOP+MOP+NOP receptors. | Buprenorphine | opioid receptor mu 1 | Homo sapiens |
| 3 | Chronic exposure to buprenorphine induced concentration-dependent AC superactivation in cells expressing KOP+NOP receptors, and the level of this superactivation was even higher in KOP+MOP+NOP-expressing cells. | Buprenorphine | opioid receptor mu 1 | Homo sapiens |
| 4 | Our study demonstrated that MOP receptor could enhance AC regulation in the presence of coexpressed KOP and NOP receptors, and NOP receptor is essential for concentration-dependent AC superactivation elicited by chronic buprenorphine exposure. | Buprenorphine | opioid receptor mu 1 | Homo sapiens |