Title : FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes.

Pub. Date : 2015 Sep

PMID : 26148725






1 Functional Relationships(s)
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1 In a closed endocrine loop, 1,25-dihydroxyvitamin D3 (1,25D) induces the expression of fibroblast growth factor 23 (FGF23) in bone, with the phosphaturic peptide in turn acting at kidney to feedback repress CYP27B1 and induce CYP24A1 to limit the levels of 1,25D. Calcitriol cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus