Title : Arsenic-induced S phase cell cycle lengthening is associated with ROS generation, p53 signaling and CDC25A expression.

Pub. Date : 2015 Aug 5

PMID : 26148435






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Importantly, it has been reported that arsenic induces reactive oxygen species (ROS), a process counteracted by p53. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 Importantly, it has been reported that arsenic induces reactive oxygen species (ROS), a process counteracted by p53. Reactive Oxygen Species tumor protein p53 Homo sapiens
3 Furthermore, for the first time, we demonstrate that arsenic activates p53-dependent transcription of ROS detoxification genes, such as SESN1, and by an indirect mechanism involving ATF3, genes that could be responsible for the S phase cell cycle arrest, such as CDC25A. Reactive Oxygen Species tumor protein p53 Homo sapiens