Title : Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.

Pub. Date : 2015 Sep

PMID : 26147382






1 Functional Relationships(s)
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1 Moreover, GW0742 increased both aortic Akt and endothelial nitric oxide synthase phosphorylation, and inhibited the increase in caveolin-1/endothelial nitric oxide synthase interaction, ethidium fluorescence, NOX-1, Toll-like receptor 4, tumor necrosis factor-alpha, and interleukin-6 expression, and IkappaBalpha phosphorylation found in aortae from the HFD group. GW0742 thymoma viral proto-oncogene 1 Mus musculus