Pub. Date : 2015 Aug
PMID : 26133921
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This study investigates whether combining all-trans retinoic acid (ATRA) and histone deacetylase inhibitor entinostat (ENT) can inhibit TICs and HER2 in AI-resistant cells and tumors. | Tretinoin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
2 | This study investigates whether combining all-trans retinoic acid (ATRA) and histone deacetylase inhibitor entinostat (ENT) can inhibit TICs and HER2 in AI-resistant cells and tumors. | Tretinoin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
3 | Modulation of cell viability and HER2 expression were assessed in AI-resistant cells treated with ATRA + ENT. | Tretinoin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
4 | Treatment with ATRA + ENT reduced HER2 expression and viability (P < 0.001) in AI-resistant cells, as well as decreased SP (P < 0.0001), mammosphere formation (P < 0.01), and expression of TIC molecular markers (P < 0.01) in LTLT-Ca. | Tretinoin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |