Title : Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist.

Pub. Date : 2015 Dec

PMID : 26132275






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1 The current results indicate that the combined use of small doses of a peripherally acting alpha2-adrenoceptor antagonist with a sulphonylurea drug could provide a novel option for the treatment of type 2 diabetes, especially in patients with increased tonic alpha2-adrenoceptor-mediated inhibition of insulin secretion. Sulfonylurea Compounds insulin Homo sapiens