Title : Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTCP) via Fusion to a High Affinity, Multimeric βTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors.

Pub. Date : 2015

PMID : 26121597






9 Functional Relationships(s)
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1 Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (betaTCP) via Fusion to a High Affinity, Multimeric betaTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. beta-tricalcium phosphate epidermal growth factor Homo sapiens
2 Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (betaTCP) via Fusion to a High Affinity, Multimeric betaTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. beta-tricalcium phosphate epidermal growth factor Homo sapiens
3 Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (betaTCP) via Fusion to a High Affinity, Multimeric betaTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. beta-tricalcium phosphate epidermal growth factor Homo sapiens
4 Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (betaTCP) via Fusion to a High Affinity, Multimeric betaTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. beta-tricalcium phosphate epidermal growth factor Homo sapiens
5 Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (betaTCP) via Fusion to a High Affinity, Multimeric betaTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. beta-tricalcium phosphate epidermal growth factor Homo sapiens
6 Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (betaTCP) via Fusion to a High Affinity, Multimeric betaTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. beta-tricalcium phosphate epidermal growth factor Homo sapiens
7 The objective of this study was to identify a facile means of tethering EGF to clinically-relevant betaTCP scaffolds and to demonstrate the bioactivity of EGF tethered to betaTCP using stimulation of the proliferative response of human bone-marrow derived mesenchymal stem cells (hBMSC) as a phenotypic metric. beta-tricalcium phosphate epidermal growth factor Homo sapiens
8 When a single copy of this betaTCP-binding peptide sequence was fused to EGF via a flexible peptide tether domain and expressed recombinantly in E. coli together with a maltose-binding domain to aid purification, the resulting fusion protein exhibited modest affinity for betaTCP. beta-tricalcium phosphate epidermal growth factor Homo sapiens
9 When a single copy of this betaTCP-binding peptide sequence was fused to EGF via a flexible peptide tether domain and expressed recombinantly in E. coli together with a maltose-binding domain to aid purification, the resulting fusion protein exhibited modest affinity for betaTCP. beta-tricalcium phosphate epidermal growth factor Homo sapiens