Title : Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.

Pub. Date : 2015 Aug 1

PMID : 26112218






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Knocking-down of PKM2 significantly enhanced gemcitabine-induced cell apoptosis through the activation of caspase 3/7 and PARP cleavage, and this inhibitory activity was associated with p38-mediated activation of p53 phosphorylation at serine 46. gemcitabine tumor protein p53 Homo sapiens