Title : Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.

Pub. Date : 2015 Sep

PMID : 26111938






1 Functional Relationships(s)
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1 Increasing BH4 bioavailability either exogenously by BH4 supplementation or endogenously by treatment with the selective peroxisome proliferator-activated receptor--delta activator GW501516 (2 mg/kg/day, 14 days) attenuated eNOS uncoupling and decreased superoxide anion production in cerebral microvessels of Tg2576 mice (p < 0.05). tg2576 peroxisome proliferator activator receptor delta Mus musculus