Title : Differential modulating effects of retinoic acid on interferon antiviral activity.

Pub. Date : 1989

PMID : 2610595






3 Functional Relationships(s)
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1 Thus, while RA (0.1-50 microM) invariably suppressed the activity of IFN-alpha, it enhanced the action of IFN-beta at low dose (0.1-1.0 microM) but became suppressive at higher concentrations (greater than or equal to 10 microM). Tretinoin interferon alpha 1 Homo sapiens
2 Furthermore, higher antiviral activity was consistently obtained when RA (0.1-10 microM) was added prior to either IFN-alpha or IFN-beta comparing to cultures with IFN alone. Tretinoin interferon alpha 1 Homo sapiens
3 Furthermore, higher antiviral activity was consistently obtained when RA (0.1-10 microM) was added prior to either IFN-alpha or IFN-beta comparing to cultures with IFN alone. Tretinoin interferon alpha 1 Homo sapiens