Title : Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.

Pub. Date : 2015 Jun 24

PMID : 26104484






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Potassium NLR family pyrin domain containing 3 Homo sapiens