Title : Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.

Pub. Date : 2015 Nov

PMID : 26100496






2 Functional Relationships(s)
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Protein Name
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1 Depletion of uric acid or ATP, or lack of ATP signaling attenuated ASH and prevented inflammasome activation and its major downstream cytokine, IL-1beta. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 CONCLUSIONS: Our data indicate that the second signal in inflammasome activation and IL-1beta production in ASH results from the endogenous danger signals, uric acid and ATP. Adenosine Triphosphate interleukin 1 beta Mus musculus