Title : Early Growth Response Protein-1 Expression by Insulin-Like Growth Factor-1 Requires ROS-Dependent Activation of ERK1/2 and PKB Pathways in Vascular Smooth Muscle Cells.

Pub. Date : 2016 Jan

PMID : 26084532






1 Functional Relationships(s)
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1 Treatment of VSMC with IGF-1 enhanced Egr-1 protein levels in a time and dose-dependent fashion and PD98059 and SP600125, two selective inhibitors of ERK1/2 and JNK, respectively, significantly decreased IGF-1-induced increase in Egr-1 expression in these cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 8 Homo sapiens