Pub. Date : 2015
PMID : 26082716
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1alpha pathway on the brain of APP/PS1 transgenic mice. | Deferoxamine | mitogen-activated protein kinase 14 | Mus musculus |
| 2 | Western blotting studies revealed that DFO differentially enhanced the phosphorylation of mitogen-activated protein kinase (MAPK)/P38 kinase in vitro and in vivo. | Deferoxamine | mitogen-activated protein kinase 14 | Mus musculus |
| 3 | The results suggest that the DFO may up-regulate several HIF-1-dependent neuroprotective-adaptive genes in AD via activating P38/HIF-1alpha pathway, which may serve as important therapeutic targets to the disease. | Deferoxamine | mitogen-activated protein kinase 14 | Mus musculus |