Pub. Date : 2015 Oct
PMID : 26082174
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis. | Proline | aldehyde dehydrogenase 18 family member A1 | Homo sapiens |
| 2 | Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis. | Proline | aldehyde dehydrogenase 18 family member A1 | Homo sapiens |
| 3 | Mechanistically, targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis, which could be reversed with proline supplementation. | Proline | aldehyde dehydrogenase 18 family member A1 | Homo sapiens |
| 4 | Thus, targeting ALDH18A1 in melanoma can be used to disrupt proline biosynthesis to limit cell metabolism thereby increasing the cellular doubling time mediated through the GCN2 pathway. | Proline | aldehyde dehydrogenase 18 family member A1 | Homo sapiens |