Title : Identification of amino acids involved in histamine potentiation of GABA A receptors.

Pub. Date : 2015

PMID : 26074818






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, we found that histamine modulation is dependent on the amino acid residues alpha1(R120), beta2(Y157), beta2(D163), beta3(V175), and beta3(Q185). Histamine adrenoceptor alpha 1D Homo sapiens
2 We showed that the amino acid residues beta2(Y157) and beta3(Q185) mediate the positive modulatory effect of histamine on GABA-induced currents, whereas alpha1(R120) and beta2(D163) form a potential histamine interaction site in GABAARs. Histamine adrenoceptor alpha 1D Homo sapiens