Title : SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Pub. Date : 2015 Aug

PMID : 26020121






3 Functional Relationships(s)
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1 OBJECTIVE: Organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1 gene) is a hepatic uptake transporter, and its genetic variability is associated with pharmacokinetics and muscle toxicity risk of simvastatin. Simvastatin solute carrier organic anion transporter family member 1B1 Homo sapiens
2 OBJECTIVE: Organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1 gene) is a hepatic uptake transporter, and its genetic variability is associated with pharmacokinetics and muscle toxicity risk of simvastatin. Simvastatin solute carrier organic anion transporter family member 1B1 Homo sapiens
3 OBJECTIVE: Organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1 gene) is a hepatic uptake transporter, and its genetic variability is associated with pharmacokinetics and muscle toxicity risk of simvastatin. Simvastatin solute carrier organic anion transporter family member 1B1 Homo sapiens