Title : Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells.

Pub. Date : 2015 Jun 20

PMID : 26008966






4 Functional Relationships(s)
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1 Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients" cells. Rimonabant cannabinoid receptor 1 Homo sapiens
2 This finding prompted us to investigate the therapeutic exploitation of CB1 inactivation by SR141716 treatment, with regard to its direct and indirect cell-mediated effects against gliomas. Rimonabant cannabinoid receptor 1 Homo sapiens
3 These results indicate that CB1 and STAT3 participate in a new oncogenic network in the complex biology of glioma and their expression levels in patients dictate the efficacy of the CB1 antagonist SR141716 in multimodal glioma destruction. Rimonabant cannabinoid receptor 1 Homo sapiens
4 These results indicate that CB1 and STAT3 participate in a new oncogenic network in the complex biology of glioma and their expression levels in patients dictate the efficacy of the CB1 antagonist SR141716 in multimodal glioma destruction. Rimonabant cannabinoid receptor 1 Homo sapiens