Pub. Date : 2015 Aug 15
PMID : 26006730
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Requirement of ERalpha and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | This study explores the mechanism of Cd-induced activation of MAPK/ERK pathway. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Cd treatment increased both the SRE reporter activity and ERK1/2 phosphorylation in a concentration-dependent manner. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Based on these results, it is concluded that not only ERalpha, but also basal activities of EGFR and Src kinase are essential for Cd-induced signal transduction and activation of MAPK/ERK pathway for breast cancer cell proliferation. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |