Pub. Date : 2015 Aug 1
PMID : 26004871
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells. | Cisplatin | alpha 1,4-galactosyltransferase (P blood group) | Homo sapiens |
| 2 | RESULTS: The cisplatin-resistant cells expressed increased cell surface Gb3. | Cisplatin | alpha 1,4-galactosyltransferase (P blood group) | Homo sapiens |
| 3 | CONCLUSIONS: Cell surface Gb3 expression is a likely tumour biomarker for acquired cisplatin resistance of NSCLC and MPM cells. | Cisplatin | alpha 1,4-galactosyltransferase (P blood group) | Homo sapiens |
| 4 | Therapy with GCS activity inhibitors or toxin targeting of the Gb3 receptor may substantially reduce acquired cisplatin drug resistance of NSCLC and MPM cells. | Cisplatin | alpha 1,4-galactosyltransferase (P blood group) | Homo sapiens |