Title : Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice.

Pub. Date : 2015

PMID : 25998889






4 Functional Relationships(s)
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1 Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice. Bleomycin angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus
2 RESULTS: Exogenous ACE2 attenuated bleomycin-induced lung fibrosis by reversing the reduction of local ACE2 and by suppressing the elevation of AGT. Bleomycin angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus
3 RESULTS: Exogenous ACE2 attenuated bleomycin-induced lung fibrosis by reversing the reduction of local ACE2 and by suppressing the elevation of AGT. Bleomycin angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus
4 CONCLUSION: ACE2 attenuated bleomycin-induced lung fibrosis as an anti-inflammatory anti-apoptotic and anti-fibrotic agent, and it might be a promising therapeutic target for IPF. Bleomycin angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus