Title : LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

Pub. Date : 2015 May 22

PMID : 25998567






2 Functional Relationships(s)
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1 Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is activated downstream of growth factors, energy signalling and intracellular essential amino acids (EAAs) such as Leu. Leucine CREB regulated transcription coactivator 1 Mus musculus
2 We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation. Leucine CREB regulated transcription coactivator 1 Mus musculus